Diagnostic Proteomics: Will this impact the clinic?

Diagnostic proteomics: will this impact the clinic?

Sascha Sauer Over the last decades we have witnessed enormous progress in the life sciences in terms of in-depth knowledge but less in the development of groundbreaking new concepts. Modern life sciences are dominated by application of the very successful reductionist research paradigm of experimental physics and chemistry [1]. However, experimental manipulation and simple mechanistic interpret...

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Protein set analyses: how could this impact the clinic?

Over the last century, the life sciences have generated important insights in functional processes of life, mainly due to the broad introduction of reductionism and experimental manipulation in biology and medical research during the 20th century [1]. On the basis of this extremely successful research paradigm, amongst others, scientists rationally dissected multiple molecular mechanisms of ‘li...

The feminization of aging: how will this impact on health outcomes and services?

We conducted an integrative review to identify issues and challenges that face aging women and to distinguish areas for future research. We found that many older women continue to face inequities related to health and often are invisible within the discourse of aging policy. In this article we argue for a greater focus on the unique needs of women, a gendered approach to policy and intervention...

How Useful Will Functional Proteomics Data Be?

Large-scale protein interaction maps are, with gene expression profiles, among the first examples of data sets generated without specific knowledge on functions of genes. These are technology-driven experiments rather than hypothesis-driven experiments. They are valuable tools for protein function prediction, despite the occurrence of typical artifacts. These approaches are still in their early...